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Biology: Structure and function

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Biology: Structure and function
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1. The Four Main Components of Blood

Blood is a vital liquid tissue that connects all parts of your body. It is not just a red fluid; it is a complex mixture. If you were to separate blood, you would find it is made of four main components. About 55% of blood is a yellowish liquid called blood plasma. The other 45% is made up of different types of cells: red blood cells, white blood cells, and tiny cell fragments called platelets. Each component has a specific and crucial job.

Key term

Blood: A liquid tissue composed of plasma, red blood cells, white blood cells, and platelets, which circulates through the body delivering essential substances and removing waste.

Fun fact

The average adult has about 5 litres of blood, and it takes about 60 seconds for a single blood cell to travel all the way around the body and back to the heart.

Worked example 14 marks

A sample of blood is separated into its main parts. List the four main components of blood and state the function of each.

  1. 1
    1. Blood Plasma: This liquid part transports cells, dissolved nutrients (like glucose), carbon dioxide, urea, and hormones.
  2. 2
    1. Red Blood Cells: These cells transport oxygen from the lungs to the body's tissues.
  3. 3
    1. White Blood Cells: These cells are part of the immune system and defend the body against pathogens.
  4. 4
    1. Platelets: These are small cell fragments that help the blood to clot at a wound site, preventing excessive bleeding and blocking entry of pathogens.

Recap

  • Blood is a liquid tissue made of plasma, red blood cells, white blood cells, and platelets.
  • Plasma is the liquid matrix that transports substances.
  • Red blood cells carry oxygen.
  • White blood cells fight disease.
  • Platelets are cell fragments involved in blood clotting.

Quick check

  1. Name the liquid part of the blood.1 mark
  2. Which component of blood is responsible for clotting?1 mark

2. Blood Plasma: The Transport System

Blood plasma is the straw-coloured liquid that makes up more than half of your blood's volume. It is about 90% water, which makes it an excellent solvent. Its main job is transport. It carries the blood cells around the body. It also transports a huge variety of dissolved substances. These include: waste carbon dioxide from body cells to the lungs; digested food products like glucose and amino acids from the small intestine to other cells; waste products like urea from the liver to the kidneys; and chemical messengers called hormones.

Key term

Blood Plasma: The pale yellow liquid component of blood that holds the blood cells in suspension and transports dissolved substances.

Examiner insight

Examiners reward answers that list specific examples of substances transported by plasma, such as glucose, amino acids, carbon dioxide, and urea.

Worked example 13 marks

Other than blood cells, list three different types of substances transported by blood plasma and state where they are transported from and to.

  1. 1
    1. Carbon Dioxide: Transported from respiring body cells to the lungs to be exhaled.
  2. 2
    1. Urea: A waste product transported from the liver (where it is made) to the kidneys to be excreted in urine.
  3. 3
    1. Glucose: A nutrient transported from the small intestine (after digestion) to all body cells for respiration.

Recap

  • Blood plasma is mostly water and makes up about 55% of blood volume.
  • Plasma transports blood cells, platelets, and dissolved substances.
  • Key substances transported include CO2, urea, glucose, amino acids, and hormones.
  • Plasma helps distribute heat around the body.

Quick check

  1. Name two waste products transported in blood plasma.2 marks

3. Red Blood Cells: Oxygen Carriers

Red blood cells are highly specialised cells designed for one main purpose: transporting oxygen. To do this job perfectly, they have several key adaptations. Firstly, they are packed with a red protein called haemoglobin. In the lungs, where oxygen concentration is high, oxygen binds with haemoglobin to form a bright red compound called oxyhaemoglobin. This is a reversible reaction. When the blood reaches body tissues where oxygen concentration is low, the oxyhaemoglobin breaks back down, releasing oxygen for the cells to use in respiration. Secondly, red blood cells have a unique biconcave disc shape, which gives them a large surface area to volume ratio for faster diffusion of oxygen. Thirdly, mature red blood cells have no nucleus, which frees up more space to pack in even more haemoglobin.

Haemoglobin + Oxygen <=> Oxyhaemoglobin

Key term

Haemoglobin: The iron-containing protein found in red blood cells that binds reversibly with oxygen.

Examiner insight

Marks are often awarded for explaining *how* an adaptation helps the function. For example, do not just say 'it has a biconcave shape'; say 'it has a biconcave shape to provide a large surface area for rapid diffusion of oxygen'.

Common pitfall

A common mistake is stating that red blood cells 'have no nucleus so they can squeeze through capillaries'. While they do squeeze through, the main reason for having no nucleus is to maximise space for haemoglobin.

Worked example 14 marks

Explain how the structure of a red blood cell is adapted to its function of transporting oxygen.

  1. 1
    1. Contains haemoglobin: This protein specifically binds with oxygen in the lungs to form oxyhaemoglobin.
  2. 2
    1. No nucleus: This maximises the internal space of the cell, allowing it to carry more haemoglobin and therefore more oxygen.
  3. 3
    1. Biconcave disc shape: This creates a large surface area to volume ratio, which allows for faster diffusion of oxygen into and out of the cell.
  4. 4
    1. Flexible membrane: Allows the cell to change shape to squeeze through narrow capillaries to reach all body tissues.

Recap

  • Red blood cells transport oxygen from the lungs to the body tissues.
  • They contain haemoglobin, a protein that binds with oxygen.
  • The reaction is reversible: haemoglobin and oxygen form oxyhaemoglobin in the lungs.
  • Adaptations include a biconcave shape, no nucleus, and a flexible membrane.
  • The biconcave shape provides a large surface area to volume ratio for efficient diffusion.

Quick check

  1. What is the name of the substance formed when haemoglobin combines with oxygen?1 mark
  2. State one reason why having no nucleus is an advantage for a red blood cell.1 mark

4. White Blood Cells: Your Body's Army

White blood cells are your body's defence force against invasion by harmful microorganisms called pathogens (like bacteria and viruses). Unlike red blood cells, they have a nucleus and come in different types. The two main types you need to know are phagocytes and lymphocytes. Phagocytes act like security guards, engulfing and digesting any pathogens they encounter. This process is called phagocytosis. Lymphocytes are like a special forces unit. They recognise specific pathogens and produce proteins called antibodies. These antibodies lock onto the pathogens, either destroying them directly or clumping them together for phagocytes to destroy more easily. Some lymphocytes also become 'memory cells', providing long-term immunity.

Key term

Pathogen: A microorganism, such as a bacterium or virus, that can cause disease.

Examiner insight

Students who clearly distinguish between the non-specific action of phagocytes (engulfing any pathogen) and the specific action of lymphocytes (producing antibodies for a particular pathogen) score higher marks.

Common pitfall

Students sometimes confuse antibodies (proteins made by lymphocytes) with antibiotics (drugs used to treat bacterial infections). They are not the same.

Worked example 14 marks

Describe the two main ways in which white blood cells protect the body against pathogens.

  1. 1
    1. Phagocytosis: Some white blood cells, called phagocytes, engulf pathogens. They change shape to surround the pathogen, take it into the cell, and release enzymes to digest and destroy it.
  2. 2
    1. Antibody Production: Other white blood cells, called lymphocytes, produce proteins called antibodies. Each antibody is specific to a particular pathogen. The antibodies attach to the pathogens, which can kill them or cause them to clump together, making it easier for phagocytes to engulf them.

Recap

  • White blood cells defend the body against pathogens.
  • Phagocytes destroy pathogens by engulfing and digesting them in a process called phagocytosis.
  • Lymphocytes produce specific antibodies to destroy pathogens.
  • Antibodies are proteins that lock onto specific molecules on pathogens.
  • Pathogens are disease-causing microorganisms.

Quick check

  1. What is the name of the process where a phagocyte engulfs a pathogen?1 mark
  2. Which type of white blood cell produces antibodies?1 mark

End-of-chapter exercise

Test yourself on the whole chapter. Work through these before moving on.

  1. List the four main components of blood.2 marks
  2. What is the function of platelets?1 mark
  3. Describe the role of blood plasma in the transport of two named substances.4 marks
  4. Explain why a red blood cell is described as a 'specialised cell'. Refer to two of its features in your answer.4 marks
  5. What is a pathogen? Give one example of a pathogen.2 marks
  6. State three ways in which the structure of a typical red blood cell differs from a typical white blood cell.3 marks
  7. Explain the meaning of the following equation, including where in the body the forward and reverse reactions occur: Haemoglobin + Oxygen <=> Oxyhaemoglobin5 marks
  8. A person has an infection caused by bacteria. Describe how their phagocytes and lymphocytes would work together to fight this infection.5 marks
  9. Iron is an important mineral in the diet. Explain why a lack of iron can lead to a person feeling tired and having little energy.3 marks
  10. A blood sample is viewed under a microscope. Describe how you could distinguish between a red blood cell and a phagocyte based on their appearance.4 marks

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