Cambridge IGCSE0970

Biological molecules

Biology 0970 Chapter Notes

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Biological molecules
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1. Monomers and Polymers: Building Blocks of Life

All large biological molecules, known as polymers, are constructed from smaller, repeating subunits called monomers. Think of it like a train (the polymer) made of many identical carriages (the monomers). Organisms build the specific polymers they need by joining monomers together in a process called a condensation reaction. This reaction forms a chemical bond and releases a single molecule of water. Conversely, to break down polymers into monomers (for example, during digestion), a process called hydrolysis occurs. Hydrolysis means 'splitting with water', and it uses a water molecule to break each bond.

Monomer + Monomer → Polymer (Dimer) + Water (Condensation)

Polymer + Water → Monomer + Monomer (Hydrolysis)

Key term

Polymer: A large molecule made from many smaller, repeating subunits called monomers joined together by chemical bonds.

Examiner insight

Examiners require students to correctly name both condensation and hydrolysis and to state the role of water in each process (released in condensation, used in hydrolysis).

Common pitfall

Confusing condensation and hydrolysis. Remember: 'Condensation' builds up and 'dries out' (removes water), while 'Hydrolysis' uses water to 'lyse' (split) a molecule.

Worked example 13 marks

A polysaccharide is formed by joining 200 glucose monomers together. Calculate how many water molecules are produced during this process. Explain your answer.

  1. 1

    A condensation reaction, which releases one molecule of water, occurs every time two monomers are joined.

  2. 2

    To join 200 monomers in a chain, you need to form one fewer bond than the number of monomers.

  3. 3

    Number of bonds = Number of monomers - 1.

  4. 4

    Number of bonds = 200 - 1 = 199.

  5. 5

    Since one water molecule is released per bond formed, 199 water molecules are produced.

Recap

  • Large biological molecules are called polymers.
  • Polymers are built from small, repeating units called monomers.
  • Condensation reactions join monomers together and release water.
  • Hydrolysis reactions break polymers down into monomers and use water.
  • These reactions allow organisms to build their own specific molecules from the food they consume.

Quick check

  1. What is the name of the reaction that breaks down a large biological molecule into its smaller subunits?1 mark
  2. What small molecule is always produced during a condensation reaction?1 mark

2. Carbohydrates: Energy and Structure

Carbohydrates are molecules made of carbon, hydrogen, and oxygen atoms. Their primary role is to provide and store energy. The simplest carbohydrates are single sugar units called monosaccharides, like glucose. Glucose is the main fuel for respiration. Two monosaccharides can join to form a disaccharide, like sucrose (table sugar). When many monosaccharides join together, they form large polymers called polysaccharides. Key examples are starch (energy store in plants), glycogen (energy store in animals), and cellulose (forms the structural component of plant cell walls).

General formula for simple sugars: C_n(H₂O)_n

Glucose + Glucose → Maltose + Water

Key term

Polysaccharide: A complex carbohydrate polymer made of many monosaccharide units joined together, such as starch, glycogen, or cellulose.

Common pitfall

Mixing up the roles of the three main polysaccharides. Remember: Starch = Plant Store, Glycogen = Animal Store, Cellulose = Plant Structure.

Fun fact

Cotton is almost pure cellulose. The strength of this polysaccharide is what makes your jeans so durable!

Worked example 14 marks

Compare the structure and function of starch and glycogen.

  1. 1

    Similarity: Both are polysaccharides made from glucose monomers, and both function as energy storage molecules.

  2. 2

    Similarity: Both are large and insoluble, so they do not affect the water potential of the cell.

  3. 3

    Difference 1 (Function): Starch is the energy store in plants, while glycogen is the energy store in animals.

  4. 4

    Difference 2 (Structure): Glycogen is more highly branched than starch. This allows for faster release of glucose monomers, which is important for active animals.

Worked example 23 marks

Explain why cellulose is a suitable material for plant cell walls.

  1. 1

    Cellulose is made of long, straight chains of glucose.

  2. 2

    These chains lie parallel to each other and are cross-linked by hydrogen bonds, forming strong microfibrils.

  3. 3

    This structure provides high tensile strength, preventing the plant cell from bursting when it takes in water by osmosis and providing structural support to the plant.

Recap

  • Carbohydrates contain carbon, hydrogen, and oxygen.
  • The monomer of a carbohydrate is a monosaccharide, such as glucose.
  • Glucose is used in respiration to release energy.
  • Starch is the energy storage polysaccharide in plants.
  • Glycogen is the energy storage polysaccharide in animals.
  • Cellulose is a structural polysaccharide that makes up plant cell walls.

Quick check

  1. Name the small sugar that is the monomer for starch and glycogen.1 mark
  2. Which carbohydrate provides structural support to plant cells?1 mark

3. Lipids: Fats, Oils, and Long-Term Storage

Lipids are a diverse group of molecules that are insoluble in water, commonly known as fats and oils. They are made of carbon, hydrogen, and oxygen, but have a much lower proportion of oxygen than carbohydrates. A typical lipid, a triglyceride, is formed from one molecule of glycerol joined to three molecules of fatty acids via condensation reactions. Lipids have several vital functions: they are an excellent long-term energy store, they provide thermal insulation, they protect vital organs, and they are a key component of cell membranes.

1 Glycerol + 3 Fatty Acids → 1 Triglyceride (Lipid) + 3 Water

Key term

Triglyceride: The main type of lipid, composed of one glycerol molecule chemically bonded to three fatty acid molecules.

Examiner insight

Candidates often score highly when they can clearly state two or more distinct functions for lipids, such as insulation and energy storage, and can link these to specific examples like seals or migrating birds.

Worked example 13 marks

Explain why lipids are a better long-term energy store than carbohydrates.

  1. 1

    Per gram, lipids release more than twice as much energy as carbohydrates when respired.

  2. 2

    This means more energy can be stored in a smaller mass, which is efficient for mobile animals.

  3. 3

    Lipids are also insoluble in water, so they can be stored without affecting the cell's water potential.

Worked example 22 marks

A seal living in a cold ocean has a thick layer of blubber (fat) under its skin. State two functions of this blubber.

  1. 1

    Function 1: It acts as a thermal insulator, reducing the loss of body heat to the cold water.

  2. 2

    Function 2: It is an energy reserve, which can be respired to release energy when the seal is unable to find food.

Recap

  • Lipids are fats and oils, and are insoluble in water.
  • Most lipids are triglycerides, made from one glycerol and three fatty acids.
  • Lipids are formed by condensation reactions.
  • The main functions of lipids are energy storage, insulation, and protection.
  • Lipids provide more than double the energy per gram compared to carbohydrates.

Quick check

  1. What are the two types of molecule that make up a triglyceride?2 marks
  2. State one function of lipids other than energy storage.1 mark

4. Proteins: The Most Versatile Molecules

Proteins are polymers that carry out a vast range of functions in living organisms. They are made from carbon, hydrogen, oxygen, and nitrogen (and sometimes sulfur). The monomers of proteins are amino acids. There are about 20 different types of amino acids. They are joined together by peptide bonds in condensation reactions to form long chains called polypeptides. The specific sequence of amino acids in a polypeptide chain determines how it folds into a unique three-dimensional (3D) shape. This 3D shape is critical to the protein's function. Examples of proteins include enzymes (biological catalysts), antibodies (part of the immune system), and haemoglobin (transports oxygen).

Amino Acid + Amino Acid → Dipeptide + Water

Key term

Denaturation: The irreversible change in the specific three-dimensional shape of a protein, caused by factors like high temperature or extreme pH, leading to a loss of its biological function.

Common pitfall

Students often write that enzymes are 'killed' by heat. Enzymes are not alive, so they cannot be killed. The correct scientific term is 'denatured'.

Worked example 13 marks

Explain the importance of a protein's three-dimensional shape.

  1. 1

    A protein's specific 3D shape is essential for its function.

  2. 2

    For example, the active site of an enzyme must have a complementary shape to its substrate to catalyse a reaction.

  3. 3

    Similarly, an antibody must have a specific shape to bind to a particular antigen.

  4. 4

    If the 3D shape is lost (denaturation), the protein can no longer carry out its function.

Worked example 24 marks

Explain what happens to an enzyme if it is exposed to a temperature that is too high.

  1. 1

    High temperatures provide the atoms in the enzyme with too much kinetic energy.

  2. 2

    This causes the atoms to vibrate excessively, breaking the weak bonds that hold the protein in its specific 3D shape.

  3. 3

    The enzyme loses its shape, a process called denaturation. The active site changes shape and is no longer complementary to the substrate.

  4. 4

    As a result, the enzyme can no longer function as a catalyst. This change is irreversible.

Recap

  • Proteins are polymers made from amino acid monomers.
  • Amino acids are joined by peptide bonds to form polypeptides.
  • The sequence of amino acids determines the protein's specific 3D shape.
  • A protein's shape is crucial for its function.
  • High temperatures or extreme pH can cause a protein to denature, losing its shape and function.
  • Examples of proteins include enzymes, antibodies, and haemoglobin.

Quick check

  1. What is the monomer of a protein?1 mark
  2. What is the term for the loss of a protein's functional 3D shape?1 mark

5. Water: The Solvent for Life

Although it is an inorganic molecule (it does not contain carbon), water is essential for all living organisms. Its most important role in the context of biological molecules is as a solvent. Most of the chemical reactions that happen inside cells, collectively known as metabolism, take place in aqueous solution. This means the reacting substances (solutes) are dissolved in water (the solvent). Water's ability to dissolve a wide range of substances allows molecules like glucose and amino acids to be transported around the body in the blood plasma. Furthermore, as we have seen, water is a key reactant in all hydrolysis reactions, which are vital for breaking down large food molecules during digestion.

Key term

Solvent: A substance, typically a liquid, in which other substances (solutes) dissolve to form a solution.

Examiner insight

Examiners expect students to identify water's role as a solvent for chemical reactions and transport, and as a reactant in hydrolysis.

Fun fact

The cytoplasm inside every one of your cells is about 80% water, forming a 'soup' where all the chemistry of life happens.

Worked example 13 marks

Explain why water is important for the digestion of protein in the stomach.

  1. 1

    Proteins are large polymers that are too big to be absorbed into the blood.

  2. 2

    They must be broken down into their monomers, amino acids.

  3. 3

    This breakdown reaction is called hydrolysis.

  4. 4

    Hydrolysis reactions require water molecules to break the peptide bonds between amino acids.

  5. 5

    Water also acts as a solvent, allowing the enzyme (pepsin) and the protein to mix and react.

Recap

  • Water is a vital inorganic molecule for life.
  • It acts as a solvent for most metabolic reactions inside cells.
  • Many substances, like glucose and salts, are transported around organisms dissolved in water.
  • Water is a reactant in hydrolysis reactions, used to break down polymers.
  • The majority of an organism's body is composed of water.

Quick check

  1. State two reasons why water is important for metabolism.2 marks

End-of-chapter exercise

Test yourself on the whole chapter. Work through these before moving on.

  1. List the chemical elements found in (a) carbohydrates and (b) proteins.2 marks
  2. Describe the difference between a condensation reaction and a hydrolysis reaction, referring to polymers, monomers and water.3 marks
  3. State three different functions of lipids in the human body.3 marks
  4. Glycogen is stored in the liver and muscles. Explain why glycogen is a suitable molecule for energy storage in animals.3 marks
  5. Describe the structure of a triglyceride molecule.2 marks
  6. A protein, such as an enzyme, has a specific three-dimensional shape. Explain why this shape is important for its function.3 marks
  7. A student eats a sandwich containing bread (starch) and chicken (protein). Describe the chemical breakdown processes these two molecules must undergo to be absorbed.4 marks
  8. Compare and contrast the structure and function of starch and cellulose in a plant.5 marks
  9. An enzyme that works in the human stomach has an optimum pH of 2. Explain what would happen to the structure and function of this enzyme if it were placed in a solution with a pH of 9.4 marks
  10. A single molecule of a lipid is formed from one glycerol molecule and three fatty acid molecules. How many water molecules are produced when one lipid molecule is formed?1 mark

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